Searchable abstracts of presentations at key conferences on calcified tissues

ba0005oc4.6 | Catabolism and metabolism | ECTS2016

The myokine Irisin improves bone quality and strength

Colaianni Graziana , Cuscito Concetta , Mongelli Teresa , Pignataro Paolo , Liu Peng , Lu Ping , Mori Giorgio , Brunetti Giacomina , Yuen Tony , Sun Li , Reseland Janne , Colucci Silvia , Zaidi Mone , Cinti Saverio , Grano Maria

Irisin is a hormone-like myokine secreted from skeletal muscle in response to exercise. Considering that an intimate relationship between skeletal muscle and bone has been well established and that physical exercise physiologically stimulates the skeleton strengthening, we explored the involvement of Irisin on bone metabolism.Our findings demonstrated that the myokine Irisin improves cortical bone mass and geometry in vivo, supporting the idea t...